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Conforma HA
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Conforma
HA
CONFORMA HA
Increases in-Vitro
Collagen Production
In an in-vitro study utilizing normal human dermal fibroblasts (NHDF)
Test Samples were prepared at identical concentrations
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Test product – Conforma-HA (0.5% HA, 99.5% water)
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Comparator – (0.5% sodium hyaluronate, 99.5% water)
Experimental Methods
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Test and comparator products diluted in cell media and added to the cells at the following final concentrations: 0.003, 0.006, 0.012%
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Cellular synthesis of Procollagen type I C-peptide (PIP) in NHDF cells evaluated via ELISA.
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Ascorbic acid (0.001%) used as a positive control
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Blank control represents no product administered
Conforma-HA significantly increased the intracellular collagen synthesis by 118-158% relative to the comparator in a concentration-dependent manner
CONFORMA HA
Improves Skin Elasticity
In a Study of 22 adult females, aged 29-59 years, subjects were assigned to utilize conformationally changed-HA 0.5% HA (half the concentration of Conforma-HA) formulated with 2% 1,2-hexanediol, applied twice daily
Measurement of Skin Elasticity
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Skin elasticity was measured 3 times on both cheeks of the subject using Cutometer® MPA580 (Enviroderm, UK).
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After negative pressure was applied to the skin, the ability of the skin to return to its previous position, i.e., elasticity, is calculated as the R2 value.
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Skin elasticity improves as the R2 value increases.
##:p<0.025(=5%/2) by Friedman test, post hoc Wilcoxon signed rank test with with Bonferroni correction F: p<0.05 by repeated measures ANOVA
Conforma HA
Reduces Eye Wrinkles
In a Study of 22 adult females, aged 29-59 years, subjects were assigned to utilize conformationally changed-HA 0.5% HA (half the concentration of Conforma-HA) formulated with 2% 1,2-hexanediol, applied twice daily
Measurement of eye wrinkles
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The same area around the eyes is pictured using PRIMOS CR® (LMI Technologies, Canada) Small Field technology.
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The average roughness of the wrinkles around the eyes (Crow's feet) is expressed as a Ra (µm) value.
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As the Ra value decreases, it means that the wrinkles around the eyes are improved.
**:p<0.05 by repeated measures ANOVA, post hoc Boferroni correction
##:p<0.025(=5%/2) by Friedman test, post hoc Wilcoxon signed rank test with with Bonferroni correction
F: p<0.05 by repeated measures ANOVA
ConformaHA
Demonstrates
‘Push-Pull’ Activity
​In a study to compare the transdermal permeability of Conforma HA-mixed with Lidocaine (9.6%) and 9.6% lidocaine cream (5-MC® cream, U Pharmaceuticals, Korea) to full thickness murine abdominal skin.
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Equal volumes of Conforma-HA-Lidocaine and 5-MC cream were applied over an area of 0.64 cm2 for 5 minutes.
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Skin absorption was assayed via LC/MS/MS for lidocaine.
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Results: Conforma-HA Delivers 4.3 times more lidocaine in the first 5 minutes
This ability to facilitate movement other molecules across the skin allows the user to apply Conforma-HA with other agents to improve skin penetration
Conforma HA
CLINICAL STUDY: J Cosmet Dermatol 2022;00:1–9
Novel conformation of hyaluronic acid
with improved cosmetic efficacy
See the clinical study results for Conform HA in the following areas:
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Skin hydration
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Transepidermal water loss
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Skin elasticity
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Wrinkles (Crows feet)
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Facial Sagging
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Skin density
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Collagen synthesis
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